How does Oocyte + work ?
| CONTENTS Ovocyte + for 1 capsule | QUANTITY (mg) | QUANTITY (mg) for 2 capsules | RDA* for 2 capsules |
|---|---|---|---|
| Vitamin C (acide ascorbique) | 90 mg | 180 mg | 300 % |
| Vitamin E (tocopherol) | 15 mg | 30 mg | 300 % |
| Folacine | 100 µg | 200 µg | 100 % |
| VITAMIN B6 | 1 mg | 2 mg | 100 % |
| VITAMIN B12 | 1 µg | 2 µg | 100 % |
| Zinc | 7,5 mg | 15 mg | 100 % |
| Iron | 7 mg | 14 mg | 100 % |
| Magnesium | 150 mg | 300 mg | 100 % |
| Selenium | 25 µg | 50 µg | - |
| Manganese | 1,75 mg | 3,5 mg | - |
* Recommended daily amount of 2 capsules per day.
In order for a woman to become pregnant, 1 spermatozoon needs to fertilise 1 ovum..
This special event is the result of a natural extremely complicated mechanism. The quality of oocytes represents one of the essential items of this procedure.
Women are born with a total amount of approximately 400 000 ovarian follicles at their disposal.
The oocytes are developped in the follicles.
Once a month, the follicle evacuates 1 oocyte.
During the period of ovulation, the spermatozoa have only 24 hours in order to fertilize the oocyte.
Only one spermatozoon will be able to fertilize the oocyte. It penetrates the protective outer layer of the ovum and prevents any other spermatozoon from entering. The core of the spermatozoon merges with the core of the oocyte forming an ovum.
The chromosomes of each cell have been brought together, determinating gender and genetic features of the future embryon. The created ovum has been divided into several cells and continues to advance to the fallopian tubes in order to arrive on the fourth day in the uterine cavity. The oocyte installs itself in the cervical mucous during the period of implantation.
The process of conception has been terminated, the period of pregnancy starts now.
Quality of oocytes and variation of quantity regarding the mitochondrion DNA
There exist 50 000 to 100 000 copies of mitonchondrion DNA (DNAmt) in the female oocytes. It is true that a link exists between the quality of the oocyte’s DNA and its fertility. It has been proved that oocytes having failed during the in-vitro impregnation contain significantly less DNA than those which have obtained a standard rate of impregnation.
- Reynier P, May-Panloup P, Chrétien MF, Morgan CJ, Jean M, Savagner F, Barrière P, Malthièry Y. Mitochondrial DNA content affects the fertilizability of human oocytes. Mol Hum Reprod 2001, 7: 425- 429.
- [8] St John JC. The need to investigate the transmission of mitochondrial DNA following cytoplasmic transfer. Hum Reprod 2002 ; 17 : 1954-1958.
Vitamins, minerals, ovulation & quality of oocytes
Several studies have shown the influence of vitamins and minerals on the ovulation, the quality of oocytes and the prevention of deformity regarding the embryo.
| Micronutrients | Effect on : | Found in which food ? |
|---|---|---|
| Vitamin C | DNA | Kiwis, red fruits, tomatoes, peppers, oranges… |
| Vitamin E (tocopherol) | DNA | Sunflower oil, corn oil, grape pips, hazelnuts, almonds, wheat germ, oily fish … |
| VITAMIN B6 | Ovulation | yeast, wheat germ, calf liver, sheep liver, ham, chicken, flour, fruit and vegetables, eggs |
| VITAMIN B9 | ADN Prevention of deformity of the neural tube |
Whole wheat, spinach, egg yolk, calf liver, fennel, lettuce… |
| VITAMIN B12 | DNA | Cooked liver, oysters, smoked herring (sardines), mussels, tuna fish… |
| Selenium | DNA | eggs, meat, fish, cereals, lentils, bread… |
| Zinc | ADN hormone regulator Preparing pregnancy : the woman’s deficiency of zinc when being pregnant can provoke the embryo’s delay in growth. |
seafood, liver, meat, fish, egg yolk, whole grains… |
| Fer | Preparing pregnancy : the pregnant woman should double her daily amount of iron. | giblets, calf liver, cocoa, seashells, oysters, fish, dried abricots, meat, fowl, fresh vegetables, eggs, chocolate… |
| Magnesium | Ovulation | Whole rice, dark chocolate, lentils, spinach, almonds, specific mineral water,... |
| Manganese | Hormone regulator | Walnuts, cereals, whole wheat, pinapple, spinach, spaghetti |
Studies and researches
- Bayer R. Treatment of infertility with vitamin E. Int J Fertil 1960; 5:70–8.
- Czeizel AE, Metneki J, Dudas I. The effect of preconceptional multivitamin supplementation on fertility. Internat J Vit Nutr Res 1996;66:55–8.
- Howard JM et al. Red cell magnesium and glutathione peroxidase in infertile women -- effects of oral supplementation with magnesium and selenium. Magnesium Research, 7(1):49-57, 1994 March.
- MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338(8760):131–7.
- Mazza D. How folate can help prevent birth defects. Aust Fam Physician 28(7):719, 1999. PubMed
- Ulrich M, Kristofferson K, et al. The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part III. Congenital anomalies. An observational study. Eur J Obstet Gynecol Reprod Biol 87(2):115-8; discussion 103-4, 1999. PubMed
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